Наркология, психиатрия, онкология

vadim_shapoval@ymail.com ; vadim.shapoval@bk.ru ; Why Asian-Americans Have Better Cancer-Specific Mortality (CSM). Normally, people absorb 10% of the iron contained in the food that they eat. However, people with hemochromatosis absorb 30% of the iron. Each type of hemochromatosis is caused by mutations in a specific gene. 1 out of every 9 individuals of European ancestry carries at least one copy of the defective gene for hemochromatosis. People of Northern European descent are more prone to hemochromatosis than people from other ethnic backgrounds. In rare cases, iron overload begins before birth. Men with type 1 hemochromatosis typically develop symptoms between the ages of 40 and 60, and women usually develop symptoms after menopause. Type 1 hemochromatosis is one of the most common genetic disorders in the United States, affecting about 1 million people. Hemochromatosis is less common in Africans, Asians, Hispanics/Latinos, and American Indians. Early symptoms of hemochromatosis are nonspecific and may include fatigue, joint pain, abdominal pain, and loss of sex drive. Later signs and symptoms can include arthritis, liver disease, diabetes, heart abnormalities, and skin discoloration. The appearance and progression of symptoms can be affected by environmental and lifestyle factors such as the amount of iron in the diet and infections. Many of the patients with hemochromatosis do not find their way to hematology/oncology clinics because they are asymptomatic or clinically silent. Asymptomatic hemochromatosis is premalignant condition. Hemochromatosis can be treated simply and successfully. If phlebotomy treatment is started before too much iron has built up in the body, it can stop many of the serious problems (pre-cancers and cancers). Sideroblastic anemias are a heterogeneous group of disorders characterized by iron deposits in the erythroblast mitochondria. Typically, patients are asymptomatic, and the disease is discovered during a routine examination. Sideroblastic anemia may lead to leukemia. Compared to whites, African Americans appear to have lower serum transferrin saturation (TS), higher serum ferritin levels, lower bilirubin levels, and lower leukocyte counts. Race and ethnicity are involved in iron metabolism. High levels of ferritin can indicate an iron storage disorder (ferritin is the major iron storage protein of the body). If parents have abnormal iron-related genes, malignancies can genetically affect children. Asian Americans have better/lower cancer-specific mortality (CSM) because they have better iron-related genes. All cancers are iron-associated or iron-related diseases, the Father of Oncology says. Cancers are caused by iron-related genes (genes directly/indirectly involved in iron metabolism) or/and iron-related events (chemical carcinogens, radiation and viruses distort iron metabolism). Stalin, Churchill, Mao and Deng Xiaoping were well-known smokers. Precancers and smoking-associated cancers can be neutralized through iron-deficiency genes and events. Local/regional iron overload (pre-cancer) can be inherited or acquired. Anyone can get cancer at any age, but clinical iron-deficiency methods can successfully eliminate tumors, metastases and micrometastases. www.medicalnewstoday.../184070 ; plus.google.com/1071.../RkPmicYQ8ju ; www.facebook.com/The...658257930905936 ; www.esosedi.ru/onmap.../index.html ; еСоседи & Google & Facebook & Vadim Shapoval